![]() ![]() Notably, Elav represses an unannotated splice isoform of fne, switching the normally cytoplasmic Fne towards the nucleus in elav mutants. These factors promote accumulation of chromatin-associated, 3’ UTR-extended, nascent transcripts, through inhibition of proximal polyadenylation site (PAS) usage. Here, we show that three ELAV/Hu RNA binding proteins (Elav, Rbp9 and Fne) have similar capacities to induce a lengthened 3’ UTR landscape in an ectopic setting. ![]() However, the factors and mechanisms that control neural APA isoforms are not well-understood. The tissue-specific deployment of highly extended neural 3’ UTR isoforms, generated by alternative polyadenylation (APA), is a broad and conserved feature of metazoan genomes.
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